The necessary nitrogen atom: a versatile, versatile design element for biomedical synthesis. The case of quinolines in pharmaceuticals (J. Med. Chem. 62, 3552-3579 (2018))
Nitrogen, oxygen and sulfur can be found in the carbon frameworks of the active ingredients in pharmaceuticals and agricultural products. A simple way to create analogues of biologically active compounds would be provided by modifying the skeletons with a different element. However, this conceptually straightforward and potentially versatile transformation is missing from much of the extensive repertoire of reactions used for organic synthesis. In a paper in Nature, Woo et al.1 present a practical strategy for replacing a carbon atom with a nitrogen atom in molecules known as quinolines, which are often found in pharmaceuticals — providing an inspiring example of a single-atom substitution.
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Citation of Cyclic Acids as Restriction Enzymes and their Use in DNA Cutter: The Case of AMG 232
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Formamide-Catalyzed Nucleophilic Substitutions and Their Role in Neurokinin Reservoir Transmembranes
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The model of Formamide-catalyzed nucleophilic substitutions and their mechanism of action are presented. There was an article in theACS Catal.10 in 2020.