The hunter-gatherer lifestyle has a thriving gut microbiome

Diarrheal Disease Research, Collaboration and Teamwork at Washington University: A Community of Scholars and Future Quasi-Teachers

What are their weaknesses? So can they talk about it so that the questions we create for them and how they feel about me are related to one another, not only in terms of our relationship, but with the community of people as well?

Fundamentally, it begins with the gift of attention and trying to look at the world through another person’s eyes, understand what inspires them, how they view their needs.

Professor Gordon strongly believes in working in a supportive environment where each person, whether in Dhaka, Bangladesh, or in his lab at Washington University School of Medicine in St Louis, feel safe enough to take the chance to develop themselves to the best of their abilities.

Because they in St Louis, they are doing the assays, the DNA work, the sophisticated work, but then it would be great for them to look at the conditions in which the patients live slip, and how do the patient’s look like you know. I think that this will empower them more.

They have done something that is critical to the journey of the lab, our relationship with one another and our connections to our colleagues in Bangladesh.

People from the International Centre for Diarrheal Disease Research can come to Washington University for six months at a time and take a deep dive into the experimental and computational pipelines that we use.

It is also to give young people a chance to pursue their careers in science locale where they practice their science and learn more about it.

The ability to create and deploy programs for a wide variety of problems is achieved by the training of very talented individuals who know how to perform certain tests.

The concept of team and teamwork is very important for how Professor Gordon and Dr Ahmed make international collaboration successful, and how they operate locally.

And that’s a shared belief that discovery and innovation occurs, is born, in a very caring, very supportive and respectful and trusting environment, so that we could share ideas with one another, and at the same time not be afraid to say “I don’t understand.”

The group of students who come to the lab to share their lives with me, all embark on a journey that’s very unique, reflecting their hopes, their dreams, their previous life experiences, their current strengths, as well as their ambitions for acquiring new capabilities.

We are a long way from each other. But you know, we meet almost every week now. This is on a platform. We never think that you know, that it has to be very formal. Because we have been working so closely together, all of us, we are part of the same team.

Source: https://www.nature.com/articles/d41586-023-02061-2

Biological sequences from fecal microbiomes and stool samples from 167 Hadza people in Bangladesh and a case study on the impact diet had on the intestinal flora

The journey began as the shared journey looked at the hypothesis: Can there be a program of community assembly and healthy children in Bangladesh or somewhere else? Was this program not happy? And was that perturbation if it didn’t exist, causally related to the pathogenesis of undernutrition?”

The researchers sequenced microbiomes from fecal samples collected from 167 Hadza people — including infants and mothers — between 2013 and 2014. The team also generated sequence from the stool samples collected from four groups of people in Nepal in 2016 and a study on the impact diet has on the gut flora in Californication.

This can affect children. It can affect adults in low and middle income countries. We often see children and women with this terrible condition.

Dr. Ahmed has been working at the icddr,b for about 36 years, and is now also the executive director there. Dr Ahmed started his job at the icddr and has been studying nutrition.

My country is Bangladesh and I am called Tahmeed Ahmed. I am a doctor. I’m a doctor working at the International Centre for Diarrhoeal Disease Research in Bangladesh.

It became apparent that nutrient-sharing relationships are probably very important as a foundation of mutually-beneficial relationships, symbioses that existed in the gut.

Building Complexity in the Gut: Communicating with Microbes in the Microbiota, the Gut Microbiome, a Conversation with Jeffrey Gordon

They could build complexity. First inputting one member, then another, in an organized and defined way to start understanding the dialogue going on in there,

…where we would take germ-free animals, animals reared in environments where there was no microbes. And initially, one at a time, possible members of the human gut, microbial community, their microbiota,

With so many interactions happening in the gut how can we comprehend the connections and conversations going on there?

The gut is teeming with activity. There are many microbes that live there. And what Dr Gordon and his collaborators are asking is whether the microbes living in the gut are communicating with the cells that line the gut.

Hello, and thank you for listening to Working Scientist. I am Julie Gould. Jeffrey Gordon was a professor at Washington University School of Medicine in St Louis, USA and he talked about his childhood dreams.

Space-Time as a Probe of the Microbiome: New insights on the evolution of the human microbiome and the impact on the global health of the planet

When the Space Age started, members of my generation looked up to the sky in awe and contemplated what it would be like to see the Earth from other planets. I wanted to be anastrologer so I could look for new life on Mars.

And then I suggested that “Look, the kind of disease, under-nutrition, that I see is just opposite to what you see in the United States and other developed countries.

In the early morning we were eating breakfast together. And we were chatting. I was asking about the work he had done in Africa, and about the work he had done on overweight.

They fashioned an environment and formed support for one another that I think really underpins the foundations for interdisciplinary research and for human flourishing, just the idea that there’s a shared spirit. There is a shared hope, trust, kindness, and generosity, and a sense of purpose that equals the sheer joy.

“The data greatly expand our picture of the human microbiome,” says Andrew Moeller, an evolutionary biologist at Cornell University in Ithaca, New York. “I am sure there are untold stories that remain hidden in the sequences.”

The team also discovered some species that were not found in the Californian samples. The bacterium is dying out as societies become more industrialized, and only a small amount of the Nepali microbes contained it.

GG species in industrialized populations have genes associated with responding to oxidative damage. Matthew Olm, a microbiologist atSTANFORD, says that the team believes chronic inflammation in the gut can cause damage to the genes. “If you have a state of chronic inflammation, it would make sense that your gut microbiome has to adapt,” he says. These genes were not detected in the Hadza microbiomes.