The First 3D structure of a human’s smell offers clues

A comparative study of G protein-coupled receptors in the elephant olfactory gene locus and in the placental mammals (African elephants)

African elephants have a dramatic increase in the number of olfactory genes and 13 placental mammals have orthologous genes. The genome Res. 24, was published last year.

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The role of G protein-coupled receptors in cancer phenotypes: a paper by A. Nakashima and S. M. Vadevoo

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Source: https://www.nature.com/articles/s41586-023-05798-y

Crystal structure of rhodopsin in complex with a mini-Go: Probing the principles of G protein selectivity

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Source: https://www.nature.com/articles/s41586-023-05798-y

SerialEM: A software package for automatic cryo-EM imaging of homogeneous protein-ligand complexes with Sortase ligation based on -arrestin coupling

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Source: https://www.nature.com/articles/s41586-023-05798-y

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How many olfactory smell-receptor genes is needed to distinguish many smells? A scientist’s perspective on the odour-decoration problem

A single odorant can cause multiple olfactoryreceptors to function, as each one has a subset of smelly molecule called odorants. It is “like hitting a chord on a piano”, says Manglik. The idea behind hitting a combination of keys is to cause the smell of a distinct odour.

The University of California, San Francisco, has a pharmaceutical chemist who co-authored the study.

The human genome contains genes encoding 400 olfactory receptors that can detect many odours. The first mammal smell-receptor genes were discovered in rats. Researchers in the 1920s estimated that the human nose could discern around 10,000 smells3, but a 2014 study suggests that we can distinguish more than one trillion scents4.

Matthew Grubb a neuroscience professor at King’s College London says that most of the people don’t like being in any other type of cell. This means that they cannot be grown or stabilized in commonly used cell lines. It would take thousands of mice noses to replicate samples. “It’s just not feasible.”

Source: https://www.nature.com/articles/d41586-023-00818-3

Binding and shape change of the OR51E2 propionate’s carboxylic acid to arginine in a superconducting catalytic solution

The binding pocket of the OR51E2 is surrounded by specific bonds that anchor the propionate’s carboxylic acid to arginine. The shape of OR51E2 is changed by binding to propionate.