The first map of human brain cells is ground-breaking

The MitoBrainMap: Characterization of mitochondrial DNA quantity and quality in the human aged and Alzheimer’s disease brain via woodworking

Klein, H.-U. et al. Characterization of mitochondrial DNA quantity and quality in the human aged and Alzheimer’s disease brain. There is a certain word that describes it. Neurodegener. 16, 75 (2021).

The map, which the study is called the MitoBrainMap, is both Technically Impressive and conceptually Wrecking, says Riedl, who was not involved in the project.

The brain is a bit-part player. “The biology of the brain, we know now, is deeply intertwined with the energetics of the brain,” says Martin Picard, a psychobiologist at Columbia University in New York City, and a co-author of the study. 20% of the human body’s energy usage is found in the brain.

Wielding a tool typically used for woodworking, the study’s authors divided a slice of frozen human brain ― from by a 54-year-old donor who died of a heart attack ― into 703 tiny cubes. Each cube measured 3 × 3 × 3 millimetres, which is comparable to the size of the units that make up standard 3D images of the brain. “The most challenging part was having so many samples,” says Picard.

Multifaceted mitochondria: a case study in the neuroscience of single-nucleus morphology and network organization. Rev. J. Alzheimer’s Disease, Vol. 52, 12560-4330, 2001

Monzel, A. S., Enríquez, J. A. & Picard, M. Multifaceted mitochondria: moving mitochondrial science beyond function and dysfunction. Nat. Metab. 5, 546–562 (2023).

Rosenberg, A. M. et al. Brain diversity and network organization predict anxiety in male mice. Nat Commun. 14, 4726

Finnegan, J. M. Vesicular quantal size is measured by amperometry at the mast and -cells. The journal J. Alzheimer’s disease was published in 1914-1923.

Darwin, C. On the Origin of Species by Means of Natural Selection, or the Preservation of Favoured Races in the Struggle for Life 1st edn (John Murray, 1859).

Croxson, P.L., Forkel, S. J., and Thiebaut de Schotten looked at the brain structure of a primate. The following is an excerpt from the title of the novel.

Tran, M. N. et al. Single-nucleus transcriptome analysis reveals cell-type-specific molecular signatures across reward circuitry in the human brain. In the year 2021. Neuron 99, 3088–3103.

Margulies, D. S. et al. The default-mode network is a part of a large complex cortical organization. Proc. Is the Natl Acad. the best? USA 113, 12560, 12560, and 12560.

Zhang, H., Schneider, T., Wheeler-Kingshott, C. A. & Alexander, D. C. NODDI: practical in vivo neurite orientation dispersion and density imaging of the human brain. The images were taken in 1000-2010.

Cheng, W., Zhang, Y. & He, L. MRI features of stroke-like episodes in mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes. Front. Neurol. 13, 843386 was the year of the whale.

Brennan, B. P., Rauch, S. L., Jensen, J. E. & Pope, H. G. A critical review of magnetic resonance spectroscopy studies of obsessive–compulsive disorder. Biol. There are Psychiatry 73, 24–31 on offer.

Source: A human brain map of mitochondrial respiratory capacity and diversity

Mitochondrial kinetics and neurotransmitter releases in the prefrontal cortex of a human brain: is there a common bond between mitochondrial and mitochondrial glycolysis?

van Zijl, P. C. M. & Yadav, N. N. Chemical exchange saturation transfer (CEST): what is in a name and what isn’t? Magn. Reson. There is a Med 65 that goes through 928 in 2011.

Blazey, T. et al. Quantitative positron emission tomography reveals regional differences in aerobic glycolysis within the human brain. J. Cereb. Blood Flow Metab. 38, 2096–2105.

Hara, Y. et al. The monkey prefrontal cortex has a vas scrotum that is linked to working memory and improves with estrogen treatment. Proc. Natl Acad. USA 111, 486–491 was published in the journalSci.

Borsche, M., Pereira, S. L., Klein, C. & Grünewald, A. Mitochondria and Parkinson’s disease: clinical, molecular, and translational aspects. J. Park. In the year of 2021, Dis. 11, 45–60

Kwon, S-K. LKB1 regulates mitochondria-dependent presynaptic calcium clearance and neurotransmitter release properties at excitatory synapses along cortical axons. PLoS Biol. 14, e1002516 (2016).

Rath, S. et al. MitoCarta3.0: an updated mitochondrial proteome now with sub-organelle localization and pathway annotations. Nucleic Acids Res. 49, D1541–D1547 (2021).

Source: A human brain map of mitochondrial respiratory capacity and diversity

MRi-Share: Brain Structure and Energy Measurement in Temporal Lobe Epilepsy. A Case Study on Neurobiology 45

Strasser, A. et al. Glutamine-to-glutamate ratio in the nucleus accumbens predicts effort-based motivated performance in humans. The year is 2000, and the drug is titled “Neuropsychopharmacology 45.”

The brains are wired to use electric fields to sculpt neural activity. It’s a phrase that means prog. It is called Neurobiol. There are two volumes in this series, 226 and102465.

Tsuchida, A. The MRi-Share database: brain imaging in a cross-sectional cohort of 1870 university students. It’s a brain structure. It was fun. 231, 215, 205, 205, 205, 205, 205, 205

He, X. et al. Uncovering the biological basis of control energy: structural and metabolic correlates of energy inefficiency in temporal lobe epilepsy. It is a scientific discipline. The Adv. 8 is called “eabn2293”.

Shulman, R. G., Hyder, F. & Rothman, D. L. Baseline brain energy supports the state of consciousness. Proc. The journal of the scientific affairs of the Natl Acad. The United States of America 106, 11099–11101, was published in the scientific journalSci.

Source: A human brain map of mitochondrial respiratory capacity and diversity

Deaths with major depression: a talk about Boldrini, Fleming, S. J., and Mann, J. J

Fleming, S. J. et al. Unsupervised removal of systematic background noise from droplet-based single-cell experiments using CellBender. Nat. Methods 20 was done in 1912.

M Boldrini gave a talk about her book. Deaths with major depression have less granule neurons, but are associated with resilience. There is a summary of the results of the Biol. Psychiatry 85, 850– 862.

Kelly, T. M. & Mann, J. J. Validity of DSM-III-R diagnosis by psychological autopsy: a comparison with clinician ante-mortem diagnosis. The word psychiatr is an abbreviation for Psychiatr. Scand. 94, 337–343 (1996).

Source: A human brain map of mitochondrial respiratory capacity and diversity

Anatomical predictors of aphasia recovery: a tractography study of bilateral perisylvian language networks

Forkel, S. J. Anatomical predictors of aphasia recovery: a tractography study of bilateral perisylvian language networks. Brain J. Neurol. 137, 2027–2039 (2014).