Nature: https://www.nature.com/articles/d41586-025-00176-2
Health

Immune cells disrupt anti-tumour defences

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The migration of mitochondria in human gastrointestinal tumours and TILs: evidence from an immunologist at the Washington University Bioinformatics laboratory

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The team found that, in three people, both the tumours and TILs carried the same genes, suggesting that the tumours might be jumping from bad to good.

Criteria to get promotion to full professorship are very variable in different parts of the world. The authors propose that this variability results in researchers from countries that value one metric more than the other. They hope that a database of hiring practices created in this study could help institutions adjust their hiring policies to make their workforce more diverse.

J.R.B. is a member of the Scientific Advisory Board of LUCA Science, Inc.; receives research support from LUCA Science and Edgewise Therapeutics; is a consultant for Columbus Instruments; has consulted for DeciBio within the past 12 months (discontinued); receives royalties from Springer Nature Group; is an inventor on technology licensed to Columbus Instruments with royalty rights; is an inventor on pending patent applications related to the treatment of metabolic diseases (63/625,555), allergic diseases (US20210128689A1) and mitochondria transfer (018984/US) assigned to Washington University in St. Louis; and is a co-founder of and holds equity in Symbiogenix, Inc.

These findings, published today in Nature, provide the strongest evidence to date that mitochondria, cellular sub-structures that produce energy, migrate in humans and not just in cell and animal models.

I first thought that it sounded crazy, like science fiction. The data for the research seems to be there, according to an immunologist who was not involved in the research. It’s possible to be looking at a completely new biology that we weren’t looking at.

Tainted TILs were less able to divide and more likely to commit cell ‘suicide’, the team showed in cellular models. T cell exhaustion was shown by TILs that had infused alien mitochondria in mice with cancer.

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Immune evasion through transfer of mitochondria in the body

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