The human dopamine transporter has a complex relationship with cocaine

Effects of N-glycosylation on Function and Surface Trafficking of the Human Dopamine Transporter: A New Insight from the J. Biol. Phys. Lett. 279, 21012

Li, L. B. et al. The role of N-glycosylation in function and surface trafficking of the human dopamine transporter. The journal J. Biol. is related to biology. Chem. 279, 21012–21020 (2004).

mice with or without dopamine transporters had higher levels of dopamine than those with a dopamine transporter. Nature 409, 609–612 in 1996.

Investigation of transmembrane segments of human dopamine transporters mediated by endocytosis and mechanoparameter localization of antidepressants using a universal Fab module

A V. and Okorom are involved. Modifications to 1-(4-(2-bis)(4-fluorophenyl)methyl)sulfinyl)alkyl alicyclic amine improve metabolism and retain an atypical DAT inhibitor profile. J. Med. There is a record of this work, titled “Chem.3c02037 (2024).”

Bloch, J. S. et al. The development of a universal Fab module for fiducial-assisted studies. There is a Proc. Natl Acad. The USA 118 and e2115435118 are in the same field.

Henry, L. K. et al. Tyr-95 and Ile-172 in transmembrane segments 1 and 3 of human serotonin transporters interact to establish high affinity recognition of antidepressants. J. Biol. Chem 281 was published in 2006

Salomon, K. et al. Dynamic extracellular vestibule of human SERT: unveiling druggable potential with high-affinity allosteric inhibitors. Proc. The National Acad. Sci. USA 120, e2304089120 (2023).

Cremona, M. L. et al. Flotillin-1 is essential for PKC-triggered endocytosis and membrane microdomain localization of DAT. Nat. Neurosci. 14, 469–477 (2011).

U. et al. The amphetamine-based reverse transport is regulated by the dopamine transporter C terminus. Neuron 51, 417–429 (2006).

Source: Structure of the human dopamine transporter in complex with cocaine

Crystal structure of a dopamine transporter in complex with cocaine. Appl. Phys. Res. Lett. N. 88 (2006) 1015-1230

Chae, P. S. A new class of amphiphiles bearing rigid hydrophobic groups for solubilization and stabilization of membrane proteins. Chemistry 18, 9485–9490 (2012).

Pörzgen, P., Park, S. K., Hirsh, J., Sonders, M. S. & Amara, S. G. The dopamine transporter is a primordial carrier for catecholamines. Mol. Pharmacol. 59, 83–95 (2001).

Loland, C. J. LeuT is a model for the investigation of binding sites for neurotransmitters. Biochim. Biophys. The article was titled Adherence 1850, 500–510.

Borre, L., Andreassen, T F., Shi, L., Weinstein, H. and Gether, U. The second sodium site in the dopamine transporter controls cation permeation and is regulated by chloride. J. Biol. Chem. 289 was published in the year 2014).

Yamashita, A., Singh, S. K., Tsukiyama, T., Jin, Y., Gouaux, E. and others have a crystal structure of a Na+/CLS- dependent neurotransmitter transporter. Nature 437, 215–223 (2005).

S. R, Nayak and others have worked on the project. The structure of the GABA transporter 1 is revealed through the use of electron microscope. Nat. Struct. Mol. Biol. 30, 0123–1029 (2023).

Source: Structure of the human dopamine transporter in complex with cocaine

Neuroplasticity in response to inactivation of the dopamine transporter: a novel drug-induced psychostimulant abuse. (Derived version)

The impact of neurotransmitters on the brain. Int. J. Mol. There was an article in Sci. 24, 15340.

Jones, S R. et al. Profound neuronal plasticity in response to inactivation of the dopamine transporter. Proc. Natl Acad. The United States of America 95, 4029–4034 was published in 1968.

The paper was written by C.J. and loland. R-modafinil (armodafinil): a unique dopamine uptake inhibitor and potential medication for psychostimulant abuse. It is a book about Biology. Psychiatry 72, 405–413 (2012).

Source: Structure of the human dopamine transporter in complex with cocaine

All-atom structure validation for molecular crystallography. Update of CHARMM36 additive force field for lipids: validation on six lipid types

Chen, B. et al. All-atom structure validation is needed for macromolecular crystallography. Acta Crystallogr. D Biol. Crystallogr. 66 was published in 2010.

Hess, B., Bekker, H., Berendsen, H. J. C. & Fraaije, J. G. E. M. LINCS: a linear constraint solver for molecular simulations. J. Comput. There was a Chem. 18 in 1997.

J. C. had a paper entitled “Variations in the status of the field of medicine and related issues.” Epik: a software program for pKa prediction and protonation state generation for drug-like molecules. J. Comput. Aided Mol. Des. 21, 681–691 (2007).

The OPM database and the PPM web server are resources for positioning of a certain group of genes in the membranes. 40, D373, D373, D373 and D373 were included in the report.

J. B. and Klauda are both part of the group. Update of the CHARMM all-atom additive force field for lipids: validation on six lipid types. J. Phys. Chem. B 114, 7830–7843 (2010).

Lee, J. The CHARMM36 Additive Force field can be used to generate an input generator for the incomprehensible, gramms, amber, openmm, and charmm simulations. J. Chem. Theory Comput. 12, 405–413 (2016).

The simulation of liquid water has been compared by Chandrasekhar, Impey, R W. and Klein. It is referred to as J. Chem. The ps. 80, 825–856 (1988).

Source: Structure of the human dopamine transporter in complex with cocaine

Zenodo: a free web application for the simulation of the dopamine transport in complex with cocaine. J. C. et al

J. C. et al. MD simulations files for: structure of the human dopamine transporter in complex with cocaine. Zenodo is a free web application.