How to make the immune system young again

Proteomic analysis of human hematopoietic stem cells and their progenitors: a mechanism of clonal expansion

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It will be years before the approach can be tested in people, but many aspects of the stem-cell biology that underlies immune-cell production are similar between mice and humans. “It’s a really important first step,” says Robert Signer, a stem-cell biologist at the University of California, San Diego, who was not involved in the research. “I’m excited to see where they take this work next.”

For decades, researchers in Irv Weissman’s group at Stanford University in California have painstakingly tracked the fate of blood stem cells. These replenish the body’s stores of red and white blood cells, which are key components of the immune system.

In the meantime, his team will continue to study mice to learn more about other effects of the antibody therapy, such as whether it affects the rates of cancer or inflammatory diseases. Weissman says the old versus the young blood-forming system makes a big difference. It is a difference in the immune system. It’s a difference all over the body.”

A group of B-cell subsets respond to stimuli accumulated in aged mice. Blood 118, 128, and 136 occurred in 2011.

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Source: Depleting myeloid-biased haematopoietic stem cells rejuvenates aged immunity

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Source: Depleting myeloid-biased haematopoietic stem cells rejuvenates aged immunity

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Source: Depleting myeloid-biased haematopoietic stem cells rejuvenates aged immunity

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