A human transplant took place of a genetically modified pig kidneys
Chinese Studies of Human Liver Transplants: A Case Study with a Ppig-Liver Perfection in the Early Stages of Epidemics
The Chinese study could offer important insights into whether pig-Liver transplants can keep people alive for a short time.
If you are looking for a long-term transplant, you may want to look at heart and kidney transplants, because they have been promoted as possible long-term replacements. They can enable someone to repair damage to their existingLiver, or they can buy time while waiting for a human transplant.
A pig that was bred in a specialized pathogen free facility was tested negative for many diseases, including Strepse suis and Mycoplasma pneumoniae. So far, he has not seen signs of an immediate form of organ rejection and the liver is producing bile. Cooper says that this is encouraging.
The researchers have also taken daily blood samples and liver biopsies and will assess immune response, infection risk and liver function in detail. “We’re having a pathologist evaluate if there’s acute rejection,” says Dou.
The Transplantation of a Clinically Dead Person to a Liver: A Model for Living People with Hormones, Blood, and Renal Changes
The surgery was approved by the family and several university committees. According to relevant national and international regulations, it has been done.
The researchers plan to repeat the procedure in another clinically dead person later this year — and next time they will remove the person’s existing liver.
Although clinically dead people are a good model for assessing the viability of xenotransplantation in living people, they are limited because the brain undergoes hormonal changes once it ceases activity. It is not yet clear how long someone with no cognitive function can remain on a ventilator while their organ is donated, he says. The longest documented case involved a pig transplant for two months.
Yang says she hopes the team will publish detailed insights about the transplantation in peer-reviewed publications, to help determine which approach is more feasible.
Slayman received a human kidney transplant after seven years of using it. After about five years, Slayman’s transplant organ showed signs of failing, leading to his re-admission to the hospital last May. He’s since been suffering serious complications.
“I saw it not only as a way to help me, but a way to provide hope for the thousands of people who need a transplant to survive,” Slayman said in a statement released by the hospital.
“When my transplanted kidney began failing in 2023, I again trusted my care team at MGH to meet my goals of not just improving my quality of life but extending it,” Slayman said in the hospital’s statement, adding the doctors explained the “pros and cons of this procedure.”
Genetically modified pigs: A frontier in medicine and a new frontier for cloning a blood transplantation cell to save people’s lives
Several biotech companies are racing to develop a supply of cloned pigs whose DNA has been genetically modified so they won’t be rejected by the human body, spread pig viruses to people or cause other complications. NPR recently got exclusive access to a research farm breeding these animals for a company in this competition, Revivicor Inc. of Blacksburg, Va.
“We are thankful for the contribution of the patient, and for the progress of transplantation science,” stated Mike Curtis, chief executive officer for eGenesis. “This represents a new frontier in medicine and demonstrates the potential of genome engineering to change the live of millions of patients.”
There is a lot of excitement in the field of technology that can help with the shortage of organs for human transplantation. A lot of people are waiting for an organ. About 17 die every day because they can’t get one.
But the research is also raising several concerns. There is a concern that animals might spread viruses to humans. Thousands of animals are slaughtered every year in order to harvest their organs. Some also question testing these organs on gravely ill patients.
L. M. Johnson, a bioethicist at SUNY Upstate Medical University, toldNPR that they need to be very careful. “I have a lot of concerns about a therapy that is very much experimental.”
What Is Wrong with a Kidney? A Patient’s Explanation and a View of the Surgery at Massachusetts General Hospital
A four-hour surgery was performed at Massachusetts General Hospital on March 16. A few moments after the transplant, the patient’s kidney started to produce urine, a sign that it was working correctly. The operating room gave a burst of applause according to the one of the surgeons involved. “It was truly the most beautiful kidney I have ever seen,” he said in a press conference on Thursday.